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KMID : 0952820080110020049
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Journal of Korean Cleft Lip & Palate Association
2008 Volume.11 No. 2 p.49 ~ p.58
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Understanding of Fetal Surgery and Application to the Cleft Lip and Palate Patient
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Kim Soung-Min
Park Jung-Min
Myoung Hoon
Choi Jin-Young
Lee Jong-Ho
Choung Pill-Hoon
Kim Myung-Jin
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Abstract
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The development of fetal surgery has led to promising options for many congenital malformations, such as congenital diaphragmatic hernia (CDH), obstructive uropathy, twin-to-twin transfusion syndrome (TTTS), and sacrococcygeal teratoma. However, preterm labor (PTL) and premature rupture of membranes continue to be uniquitous risks for both mother and fetus. To reduce maternal morbidity and the risk of prematurity, minimal access techniques were developed and are increasingly employed recently. Lift-threatening diseases as well as severely disabling but not life-threatening conditions are potentially amenable to treatment. Recently, improvement of video-endoscopic technology has boosted the development of operative techniques for feto-endoscopic surgery, which has been demonstrated to be less invasive than the open approach. Fetal surgery for repair of cleft lip and palate, a congenital anomaly which is not life threatening, is inappropriate until such time that the benefits are shown to outweigh the risks of both the procedure itself and preterm delivery. Further animal studies will be needed before intrauterine surgery for humans should be considered. For the better understanding of recent techniques and complications associated with fetal intervention of congenital facial defect patients, we reviewed recent related articles about the current knowledge and new perspectives of experimental fetal fetal surgery in the cleft lip and palate defects.
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KEYWORD
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Fetal surgery, Fetal endoscopic surgery, Animal models, Cleft lip and palate, Preterm labor (PTL)
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